Author Archive for: ERA

Entries by ERA

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Easy estimation of renal growth rate in ADPKD

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the exponential and unlimited enlargement of the total kidney volume (TKV) associated with a decrease in renal function. In the prospective, placebo-controlled tolvaptan efficacy and safety in the management of ADPKD and its outcomes (TEMPO) 3:4 trial a mixed-model repeated-measures analysis was applied to assess a […]

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Are those really SARS-CoV-2 virions in the kidney?

Several studies report direct infection of different types of kidney cells by SARS-CoV-2 detected by transmission electron microscopy (TEM) both on post-mortem analysis and kidney biopsy specimens. However, these studies did not include detection of viral RNA or other methods for viral detection of kidney specimens and thus it is unclear whether the observed particles […]

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Is longer dialysis necessarily better? The results of the ACTIVE Trial

A Clinical Trial of IntensiVE (ACTIVE) Dialysis randomized 200 participants to extended hours (≥24 hours/week) or standard (≤18 hours/week) dialysis for 12 months to determine whether extended hours result in improved survival. After completing the 12-month study period participants could change their dialysis regimen, but continued a pre-specified observational follow-up for a further 4 years. […]

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Elbasvir and grazoprevir successfully eliminate HCV infection in HCV-naïve recipients of HCV-infected kidneys

HCV infected persons represent a growing pool of organ donors because they are typically younger and have fewer comorbidities than average donors. The introduction of direct-acting antivirals (DAAs) which successfully achieve sustained virologic response in >95% of cases has opened the door to clinical trials investigating feasibility and safety of transplantations from HCV-infected donors to […]

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Cardiovascular risk of nonsteroidal anti-inflammatory drugs occurs independently of dose and duration of exposure in dialysis patients

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed in dialysis patients, despite their well-established adverse effects. A case cross-over study was conducted by Joo et al. to assess the association of NSAIDs with major adverse cardiac and cerebrovascular events (MACCEs) and mortality in dialysis patients. The results showed that nonselective NSAIDs significantly increased the risk of […]

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Dysregulated turnover of collagen type III is an important determinant of chronic kidney disease progression

Collagen type III (COL3) is one of the most abundant extracellular matrix components in the human body; decreased urinary levels of a degradation fragment of COL3 (C3M) were associated with the severity of CKD in patients with immunoglobulin A nephropathy and kidney allograft failure. Genovese et al. assessed the relationship between fragments reflecting active formation […]

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Elderly patients also benefit from kidney transplantation

So far, kidney transplantation has generally not been offered to elderly patients (>75 years) because of the perioperative risks. Nor has it been clearly established whether transplanted patients in this age benefit significantly. In a new study published in NDT, the graft survival proved to be excellent, and nearly all patients remained dialysis-free. Is it […]

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Consensus statement from the American College of Radiology and the National Kidney Foundation on the use of intravenous iodinated contrast media in patients with kidney disease

The true risk of contrast induced acute kidney injury is unknown. However, the presumed risk of administering modern intravenous iodinated contrast media in patients with reduced kidney function seems to be overstated. A recently disclosed consensus statement from the American College of Radiology and the National Kidney Foundation define the patients at high risk to […]

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Simultaneous pancreas-kidney (SPK) transplantation improves survival compared with kidney transplantation alone in patients with diabetes type 1

Patients with type 1 diabetes and end-stage kidney disease experience inferior survival on dialysis and benefit most from a pre-emptive kidney transplantation. A nationwide study conducted in the Netherlands included 2,796 patients with type 1 diabetes who started renal replacement therapy between 1986 and 2016 and compared long-term survival in those who received a SPK […]

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Aetiology and management of acute interstitial nephritis

Acute interstitial nephritis (AIN) may be a contributory factor in up to 35% of cases of acute kidney injury. The typical histological lesion is infiltration of the interstitial renal tissue by inflammatory cells. AIN can complicate a variety of diseases, including autoimmune conditions (Sjögren’s syndrome, inflammatory bowel diseases, primary biliary cholangitis and sarcoidosis), infections, oxalosis, […]