Cardiovascular disease (CVD) remains the leading cause of death in chronic kidney disease (CKD) patients. Metabolic acidosis is a risk factor for CVD and increases overall mortality risk in CKD patients, but also in the general population. An editorial by D. E. Wesson in Nephrology Dialysis Transplantation (NDT) explores available evidence on the mechanisms through […]
Urinary EGF has recently emerged as a highly promising biomarker of chronic kidney disease (CKD) progression. In recently published research, Gipson et al. investigated the possible predictive role of uEGF in the pediatric nephrotic syndrome population. The study evaluated 191 participants with nephrotic syndrome; EGF/creatinine was measured in urine and renal EGF mRNA was determined […]
Inhibition of angiotensin II (AngII) signaling is the cornerstone of management of proteinuric kidney disease. However, the relevance of AngII signaling in podocytes has thus been poorly investigated. In a recent study on mouse models, podocytes displayed limited responsiveness to AngII stimulation in healthy animals. On the other hand, proteinuric animals exhibited a notable podocyte […]
Up to 50% of patients with hepatitis C virus (HCV) infection have elevated cryoglobulin levels, but only 2-3% develop vasculiticsymptoms of HCV-related mixed cryoglobulinemia (HCV-MC). The recently introduced direct antiviral agents (DAA) have yielded high rates of sustainable viral response in chronic HCV infection, even in chronic kidney disease patients. The RENALCRYOGLOBULINEMIC observational multicentre cohort […]
The new GlomCon/ERA-EDTA roundtable discussion is scheduled tomorrow, February 14, 2020 at 5 pm CET, 4 pm GMT and 8 am PST. Dr Rianne Boenink will discuss on “Trends in Excess Mortality in European Adult Patients on Renal Replacement Therapy”. The moderator will be Dr Sokratis Stoumpos and the panelists will be Prof Kitty J. […]
The webcast of the CTDay (Clinical Transplantation Day), held on November 29,2019 in Barcelona (Spain), is available on the ERA-EDTA website. The access to the webcast is for healthcare professionals only. View the webcast https://www.era-online.org/en/virtual-meeting/#!resourcegroups/event_ids=253&page=1
Both malnutrition and obesity are important problems in children with chronic kidney disease (CKD). The latest recommendations from the Pediatric Renal Nutrition Taskforce wererecently published to help guide nutritional recommendations for children with CKD stages 2–5 and those on dialysis. They emphasize the importance of breastfeeding or feeding with breastmilk for infants with CKD. The […]
Serum levels of soluble urokinase-type plasminogen activator receptor (suPAR) are increased in inflammation and have been associated with endothelial dysfunction and cardiovascular risk. Patients with nephrotic syndrome (NS) show signs of endothelial dysfunction and so suPAR levels were evaluated in 152 patients with idopathic NS due to minimal change disease, focal segmental glomerulosclerosis or membranous […]
The newest results from the prospective cohort Dialysis Outcomes and Practice Patterns Study (DOPPS) in the Gulf Cooperation Council (GCC) describe Kt/V achievement, its predictors and its relationship with mortality. The analysis included 1544 patients aged ≥18 years dialyzed for at least 180 days in Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and the United Arab […]
Pre-emptive transplantation is the optimum renal replacement therapy in terms of increasing life expectancy, improving quality of life and achieving the highest cost-effectiveness. Planning for the procedure requires an understanding of the following technical preconditions for successful transplant surgery: arterial and venous factors, urinary drainage, organ and recipient factors. Vasculature should be carefully evaluated in […]
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