Author Archive for: ERA

Entries by ERA

The first steps in the use of belimumab in membranous nephropathy

In a new issue of Nephrology Dialysis Transplantation, authors assessed the effect of belimumab on proteinuria and PLA2R serology in patients with PLA2R-related membranous nephropathy. In a new issue of Nephrology Dialysis Transplantation, Belson et al. assessed the effect of belimumab on proteinuria and PLA2R serology in patients with PLA2R-related membranous nephropathy MN. This study […]

SPRINT trial results: Serum bicarbonate and cardiovascular events in hypertensive adults

In hypertensive individuals, serum bicarbonate level <22 mEq/L was associated with an increased CVD risk. The effect of intensive BP lowering on CVD outcomes was not modified by the serum bicarbonate level. Serum bicarbonate concentration <22 mEq/L is independently associated with a high risk of cardiovascular disease (CVD) events in hypertensive individuals, according to the results […]

Eculizumab for the treatment of children with Shiga toxin-associated hemolytic-uremic syndrome

Eculizumab treatment does not seem to improve short- or intermediate-term renal outcome after STEC-HUS in children. It appears to be safe in severe forms of STEC-HUS. Treatment with eculizumab in Shiga toxin-associated haemolytic and uraemic syndrome (STEC-HUS) remains controversial despite its increasing utilization. A new study evaluated the outcomes of children treated with eculizumab for […]

The impact of socioeconomic status on AKI incidence and survival

Social deprivation is associated with higher incidence of AKI and poorer survival even after adjusting for the higher presence of comorbidities. A new study explored the socioeconomic gradient of the incidence and mortality of AKI, after adjusting for important mediators such as comorbidities. Authors linked primary care and laboratory data from two large acute hospitals […]

Current state and pitfalls of B-cell therapy in lupus nephritis

In a recently published NDT article, the authors reviewed the current experience with B-cell therapy in LN and highlighted the pitfalls that may have limited their success. Systemic lupus erythematosus (SLE) is an autoimmune multisystem disease that commonly affects the kidneys characterized by persistent autoantibody production that targets a multitude of self-antigens. B-cells, plasmablasts and […]

Long term outcomes following acute rejection in kidney transplant recipients

The authors of a new study examined the association of AR within 6 months of kidney transplant with long-term outcomes of transplant recipients, using data from the ANZDATA Registry between 1997 and 2017. Declining rates of acute rejection (AR) and the very high rate of 1-year graft survival among patients with AR has led some […]