Does ADH modulate renal calcium excretion in patients with CDI and hypercalciuria?


Antidiuertic hormone (ADH), commonly known for regulating body’s water balance, has recently been linked to osteoporosis during ageing and microgravity/bed rest. This prompted a research on the possible role od ADH in modulating renal calcium excretion. Data for 12 patients with central diabetes insipidus (CDI) and measured 24-h urinary excretion levels of calcium have been retrospectively analyzed before and after treatment with ADH analog. The patients had hypercalciuria even though their urine was diluted compared to normal controls. ADH analog reversed this effect, supporting the intruiging relationship between ADH and osteoporosis.

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