Is longer dialysis necessarily better? The results of the ACTIVE Trial

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A Clinical Trial of IntensiVE (ACTIVE) Dialysis randomized 200 participants to extended hours (≥24 hours/week) or standard (≤18 hours/week) dialysis for 12 months to determine whether extended hours result in improved survival. After completing the 12-month study period participants could change their dialysis regimen, but continued a pre-specified observational follow-up for a further 4 years. Overall, participants were followed for a combined 877.5 patient-years. There was no improvement of long-term survival noted; suggesting that the optimal “amount” of dialysis across a broad range of dialysis recipients is yet to be defined.

Read the article at https://onlinelibrary.wiley.com/doi/abs/10.1111/nep.13737