The risks of gastrointestinal adverse events with initiation of sodium polystyrene sulphonate

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Sodium polystyrene sulphonate (SPS) has been widely used for hyperkalemia management in chronic kidney disease (CKD). However, data on its safety are scarce and ambiguous. A retrospective cohort study based on the nationwide Swedish Renal Registry examined patterns of use and adverse events associated to SPS initiation during follow-up. 3690 patients initiated SPS during follow-up, of whom 59% took SPS chronically. SPS initiation was associated with a higher incidence of both severe (mainly attributed to ulcers and perforations) events, particularly in those receiving per label doses, and minor gastrointestinal events, regardless of dose.

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