EURECA-m e-Newsletter
Year 5 Issue 2 November 2014
In this issue:
Update on the EURECA-m ESRD Cardiovascular Research Registry
Update on the EURECA-m Lung comets study (LUST) 
EURECA-m CME Course in Warsaw
EURECA-m CME Course in Iasi
EURECA-m Board Members
Gérard Michel London (EURECA-m Chairman)
Alberto Ortiz Arduan (EURECA-m Secretary)
Gunnar Heine, Germany
Mehmet Kanbay, Turkey (Co-Editor in Chief of EURECA-m Newsletter)
Francesca Mallamaci, Italy
Ziad A. Massy, France
Patrick Rossignol, France (Co-Editor in Chief of EURECA-m Newsletter)
Raymond Vanholder, Belgium
Andrzej Wiecek, Poland (liaison with National Societies of Nephrology)
EURECA-m Advisor and LUST Study Coordinator
Carmine Zoccali, Italy

EURECA-m Registry Clinical Coordinator
Francesca Mallamaci, Italy

EURECA-m External Consultant for Nutritional Aspects in Cardiovascular Diseases in CKD
Denise Fouque, France
Epidemiology and Biostatistics Consultants
Kitty J Jager, The Netherlands
Friedo W Dekker, The Netherlands
Giovanni Tripepi, Italy
Cecile Couchoud, France
OPEN CALL for EURECA-m Ordinary Members
Deadline to apply:
January 15th, 2015

Dear EURECA-m Members,

It is our pleasure to inform you about EURECA-m activities. We were elected as EURECA-m Newsletter co-Editors in Chief during the latest Board Meeting held in Warsaw.
Through the EURECA-m newsletter, we will do our best to keep you updated on all EURECA-m present and future initiatives.

Enjoy the reading and stay tuned!

Sincerely yours,

Mehmet Kanbay
Prof. Mehmet Kanbay
EURECA-m Newsletter co-Editor in Chief
Patrick Rossignol
Prof. Patrick Rossignol
EURECA-m Newsletter co-Editor in Chief
Update on the EURECA-m ESRD Cardiovascular Research Registry

As stated in previous newsletters, the first concrete initiative of EURECA-m working group was creating  an ESRD Cardiovascular Research Registry. This registry aims at a systematic collection of 24h ABPM recordings, Echocardiography and Pulse Wave Velocity (PWV) measurements, demographic and clinical data and incident clinical outcomes. In addition to that the Registry also aims  at  establishing  peripheral (centre-based) Biobanksat  in  some of the centres involved in the initiative. It is important to note that some of the centres which had initially given their adhesion to the study, finally withdrew their agreement for several reasons (i.e. problems with their ethical committee being one of the most important).
A web-based platform for the online data collection was completed by the CNR Research Unit of Reggio Calabria at the end of 2011 and the first EURECA-m patient was enrolled in January the second 2012 in Reggio Calabria, Italy. To date, the following 5 centres are actively into the project and are listed below according to the number of patients enrolled:

  1. Reggio Calabria, Italy (95 pts.)
  2. Parma, Italy (72 pts.)
  3. Ioannina, Greece (67 pts.)
  4. Homburg/Saar, Germany (40 pts.)
  5. Iasi, Romania (7 pts.)
The total number of patients already in the study is 282.
Information about comorbidities, smoking and alcohol status, therapy or the Karnofsky questionnaire  have been almost completed while echocardiographic parameters, B-lines number, pulse wave velocity and 24h ambulatory blood pressure measurements have not. In order to populate the registry with the data of the patients already in the study, during the last two months all participating centres were contacted and asked to complete the database with all available data. This amount of data is still in progress and there are encouraging signs of a  renewed interest in the project.
Although presently the number of patients is below that one we expected, it is sufficient to start some exploratory analyses of the data collected in order to encourage other members of the EURECA-m working group, which are more than 600, to join the project. It is important to underline that the quality of the data is high because, as planned at the beginning of the study, core data entered into the website have to be validated by well-known international excellence centres. So far all entered 24h ABPM exams have been validated, as well as a half of PWV exams. More work must be done for echocardiographic parameters.
To conclude this brief report, in the last EURECA-m meeting the idea that the Registry needs to be re-organized emerged  and the  structure of the ERA- EDTA Registry could serve to boost the project.  
Prof. Francesca Mallamaci
EURECA-m Registry Clinical Coordinator

Update on the EURECA-m Lung comets study (LUST) 

It is now over 1 year  that  the LUST study officially started the enrollment. At the moment, all 21 centers participating into this study received the agreement from their Ethical Committees. Unfortunately, a few centres initially selected withdrew.
A web-based platform for the online data collection was completed by the CNR Research Unit of Reggio Calabria at the end of 2013 and it was implemented using all suggestions received by LUST investigators. Bugs   have been rapidly corrected  whenever  notified  by participating centres.  The first LUST patient was enrolled on the 2nd of May, 2013. To date, 14 centres have already asked and obtained by  the  coordinating  centre  the randomization list of their patients to  start  enrollment.  As of today, 193 patients started the study.

  1. Wroclaw, Poland (33 pts.)
  2. Reggio Calabria, Italy (28 pts.)
  3. Maribor, Slovenia (27 pts.)
  4. Homburg/Saar, Germany (20 pts.)
  5. Iasi, Romania (19 pts.)
  6. Ioannina, Greece (18 pts.)
  7. Parma, Italy (12 pts.)
  8. Acquaviva delle Fonti, Bari, Italy  (10 pts.)
  9. Kallithea, Athens, Greece (10 pts.)
  10. Saint-Augustin, France (6 pts.)
  11. Paris, France (5 pts.)
  12. Nancy, France (2 pts.)
  13. Strasbourg, France (2 pts.)
  14. Madrid, Spain (1 pts.)

Baseline data for  131 patients have already been  registered  in the  study WEB-based platform. However, the database is far from being complete.  Echocardiography data and lung comets  clips  have  been uploaded by the  coordinating centre  only. The LUST study is now in  a critical phase    and    participating centres   should  make a major  effort  to  respect the  schedule  of the trial.  We  strongly  recommend all participating centres to  speed up patients  enrollment  and data  entry into the  study database, a  fundamental requirement   for the  coordinating centre  surveying  the  progress of the  study.   It is imperative that we  complete enrollment  within 6 months to comply  with  the established  milestones  of the Study. Because of the  smooth   progress  of the trial  in  Reggio Calabria and  in at least two additional centres, I  remain positive  about   the  successful  completion  of this  so important clinical trial.  From now on,  the  coordinating centre   will progressively  intensify reminders  and  contacts  with local coordinators and leaders  to advance LUST.

Prof. Carmine Zoccali
LUST Study Coordinator

EURECA-m CME Course in Warsaw

Last July 4th and 5th, 2014 the EURECA-m Board Member and the new President of the ERA-EDTA, Prof. Andrzej Wiecek, organized the 2nd EURECA-m CME Course of the year in Warsaw, Poland.

The CME Course venue was the Hotel Bristol, situated in the heart of Warsaw, on the famous Royal Route. The hotel delights with neo-renaissance facade and romantic interiors, filled with luxury finishes and Art Deco elegance and is situated next to the Presidential Palace, just a few steps from the Old Town, the Royal Castle and the 200-year-old National Theater and Opera House, with their unforgettable atmosphere and the touch of historic grandeur.

Warsaw and the Hotel Bristol also hosted the EURECA-m Board meeting held, shortly before the CME Course.
About 100 scientists from Poland, United Kingdom, Brazil and India participated in the CME Course and they all received promotional material concerning various ERA-EDTA activities.
The CME discussed of “Cardiovascular complications in patients with chronic kidney disease” in all aspects with 13 talks by experts in the field grouped into 3 sessions: READ MORE.

Prof. Andrzej Więcek
by courtesy of

EURECA-m CME Course in Iasi

Last September 5th and 6th, 2014, Prof. Adrian Covic organized, as former EURECA-m Board Member, the 3rd EURECA-m CME Course of the year in Iasi, Romania.
Iasi is a very nice city and the most important political, economic and cultural centre of the province of Moldavia as well as one of the oldest cities in Romania.
The CME was successful and innovative: the topic was “Cardiovascular Disease Risk Factors in CKD: problems and solutions”.
The CME discussed the cardiovascular risk factors in chronic kidney disease (CKD) in all aspects with 14 talks by experts in the field grouped into 4 sessions and various lectures: READ MORE:

Prof. Adrian Covic
EURECA-m Website: