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| In this issue: |
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| Update on the EURECA-m ESRD Cardiovascular Research Registry |
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| Update on the EURECA-m Lung comets study (LUST) |
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| EURECA-m CME Course in Warsaw |
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| EURECA-m CME Course in Iasi |
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| EURECA-m Board Members |
Gérard Michel London (EURECA-m Chairman) |
Alberto Ortiz Arduan (EURECA-m Secretary) |
| Gunnar Heine, Germany |
| Mehmet Kanbay, Turkey (Co-Editor in Chief of EURECA-m Newsletter) |
| Francesca Mallamaci, Italy |
| Ziad A. Massy, France |
| Patrick Rossignol, France (Co-Editor in Chief of EURECA-m Newsletter) |
Raymond Vanholder, Belgium |
Andrzej Wiecek, Poland (liaison with National Societies of Nephrology)
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EURECA-m Advisor and LUST Study Coordinator
Carmine Zoccali, Italy |
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EURECA-m Registry Clinical Coordinator
Francesca Mallamaci, Italy |
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EURECA-m External Consultant for Nutritional Aspects in Cardiovascular Diseases in CKD
Denise Fouque, France |
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Epidemiology and Biostatistics Consultants
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Kitty J Jager, The Netherlands
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Friedo W Dekker, The Netherlands
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Giovanni Tripepi, Italy
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| Cecile Couchoud, France |
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Dear EURECA-m Members,
It is our pleasure to inform you about EURECA-m activities. We were elected as EURECA-m Newsletter co-Editors in Chief during the latest Board Meeting held in Warsaw.
Through the EURECA-m newsletter, we will do our best to keep you updated on all EURECA-m present and future initiatives.
Enjoy the reading and stay tuned!
Sincerely yours,
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Prof. Mehmet Kanbay
EURECA-m Newsletter co-Editor in Chief
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Prof. Patrick Rossignol
EURECA-m Newsletter co-Editor in Chief
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Update on the EURECA-m ESRD Cardiovascular Research Registry
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As stated in previous newsletters, the first concrete initiative of EURECA-m working group was creating an ESRD Cardiovascular Research Registry. This registry aims at a systematic collection of 24h ABPM recordings, Echocardiography and Pulse Wave Velocity (PWV) measurements, demographic and clinical data and incident clinical outcomes. In addition to that the Registry also aims at establishing peripheral (centre-based) Biobanksat in some of the centres involved in the initiative. It is important to note that some of the centres which had initially given their adhesion to the study, finally withdrew their agreement for several reasons (i.e. problems with their ethical committee being one of the most important).
A web-based platform for the online data collection was completed by the CNR Research Unit of Reggio Calabria at the end of 2011 and the first EURECA-m patient was enrolled in January the second 2012 in Reggio Calabria, Italy. To date, the following 5 centres are actively into the project and are listed below according to the number of patients enrolled:
- Reggio Calabria, Italy (95 pts.)
- Parma, Italy (72 pts.)
- Ioannina, Greece (67 pts.)
- Homburg/Saar, Germany (40 pts.)
- Iasi, Romania (7 pts.)
The total number of patients already in the study is 282.
Information about comorbidities, smoking and alcohol status, therapy or the Karnofsky questionnaire have been almost completed while echocardiographic parameters, B-lines number, pulse wave velocity and 24h ambulatory blood pressure measurements have not. In order to populate the registry with the data of the patients already in the study, during the last two months all participating centres were contacted and asked to complete the database with all available data. This amount of data is still in progress and there are encouraging signs of a renewed interest in the project.
Although presently the number of patients is below that one we expected, it is sufficient to start some exploratory analyses of the data collected in order to encourage other members of the EURECA-m working group, which are more than 600, to join the project. It is important to underline that the quality of the data is high because, as planned at the beginning of the study, core data entered into the website have to be validated by well-known international excellence centres. So far all entered 24h ABPM exams have been validated, as well as a half of PWV exams. More work must be done for echocardiographic parameters.
To conclude this brief report, in the last EURECA-m meeting the idea that the Registry needs to be re-organized emerged and the structure of the ERA- EDTA Registry could serve to boost the project. |
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Prof. Francesca Mallamaci
EURECA-m Registry Clinical Coordinator
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Update on the EURECA-m Lung comets study (LUST) |
It is now over 1 year that the LUST study officially started the enrollment. At the moment, all 21 centers participating into this study received the agreement from their Ethical Committees. Unfortunately, a few centres initially selected withdrew.
A web-based platform for the online data collection was completed by the CNR Research Unit of Reggio Calabria at the end of 2013 and it was implemented using all suggestions received by LUST investigators. Bugs have been rapidly corrected whenever notified by participating centres. The first LUST patient was enrolled on the 2nd of May, 2013. To date, 14 centres have already asked and obtained by the coordinating centre the randomization list of their patients to start enrollment. As of today, 193 patients started the study.
- Wroclaw, Poland (33 pts.)
- Reggio Calabria, Italy (28 pts.)
- Maribor, Slovenia (27 pts.)
- Homburg/Saar, Germany (20 pts.)
- Iasi, Romania (19 pts.)
- Ioannina, Greece (18 pts.)
- Parma, Italy (12 pts.)
- Acquaviva delle Fonti, Bari, Italy (10 pts.)
- Kallithea, Athens, Greece (10 pts.)
- Saint-Augustin, France (6 pts.)
- Paris, France (5 pts.)
- Nancy, France (2 pts.)
- Strasbourg, France (2 pts.)
- Madrid, Spain (1 pts.)
Baseline data for 131 patients have already been registered in the study WEB-based platform. However, the database is far from being complete. Echocardiography data and lung comets clips have been uploaded by the coordinating centre only. The LUST study is now in a critical phase and participating centres should make a major effort to respect the schedule of the trial. We strongly recommend all participating centres to speed up patients enrollment and data entry into the study database, a fundamental requirement for the coordinating centre surveying the progress of the study. It is imperative that we complete enrollment within 6 months to comply with the established milestones of the Study. Because of the smooth progress of the trial in Reggio Calabria and in at least two additional centres, I remain positive about the successful completion of this so important clinical trial. From now on, the coordinating centre will progressively intensify reminders and contacts with local coordinators and leaders to advance LUST.
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Prof. Carmine Zoccali
LUST Study Coordinator
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EURECA-m CME Course in Warsaw |
Last July 4th and 5th, 2014 the EURECA-m Board Member and the new President of the ERA-EDTA, Prof. Andrzej Wiecek, organized the 2nd EURECA-m CME Course of the year in Warsaw, Poland.
The CME Course venue was the Hotel Bristol, situated in the heart of Warsaw, on the famous Royal Route. The hotel delights with neo-renaissance facade and romantic interiors, filled with luxury finishes and Art Deco elegance and is situated next to the Presidential Palace, just a few steps from the Old Town, the Royal Castle and the 200-year-old National Theater and Opera House, with their unforgettable atmosphere and the touch of historic grandeur.
Warsaw and the Hotel Bristol also hosted the EURECA-m Board meeting held, shortly before the CME Course.
About 100 scientists from Poland, United Kingdom, Brazil and India participated in the CME Course and they all received promotional material concerning various ERA-EDTA activities.
The CME discussed of “Cardiovascular complications in patients with chronic kidney disease” in all aspects with 13 talks by experts in the field grouped into 3 sessions: READ MORE.
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EURECA-m CME Course in Iasi |
Last September 5th and 6th, 2014, Prof. Adrian Covic organized, as former EURECA-m Board Member, the 3rd EURECA-m CME Course of the year in Iasi, Romania.
Iasi is a very nice city and the most important political, economic and cultural centre of the province of Moldavia as well as one of the oldest cities in Romania.
The CME was successful and innovative: the topic was “Cardiovascular Disease Risk Factors in CKD: problems and solutions”.
The CME discussed the cardiovascular risk factors in chronic kidney disease (CKD) in all aspects with 14 talks by experts in the field grouped into 4 sessions and various lectures: READ MORE:
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