Hot topics in Nephrology

Topic Atypical Haemolytic Uraemic Syndrome

A 37 year old man with end stage renal failure, secondary to atypical haemolytic uraemic syndrome (aHUS), is being worked up to receive a live donor kidney from his wife. He has two children and asks about the likelihood of them inheriting his condition.

A mutation in the gene encoding which of the following proteins most commonly predisposes to aHUS?