NDT Kidney Art Gallery

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The title of the painting is “Stained”.  It is inspired by the immunoflourescent staining of glomeruli done in the histopathologic evaluation of glomerular disease.

From:
Mayleen Laico, Philippines

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Human glomerulus (podocin in green, synaptopodin in magenta)

From:
Nicole Endlich, Germany

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This confocal image shows a cryosection of a larval zebrafish glomerulus at 5 days post fertilization. The endogenously expressed eGFP under control of the nphs2 promotor labels podocytes in green, including the major processes. Magenta depicts the glomerular endothelial cells with an antibody against Ehd3.

From:
Maximilian Schindler, Germany
Department of Anatomy and Cell Biology, University Medicine Greifswald, Nicole Endlich’s Lab

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Aquarelle painting called ‘Care for your Kidneys’.

From:
Jeanine Verbeke, Belgium

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Combination of (i) immunofluorescence images stained for IgA and (b) renal magnetic resonance angiography images, in a patient with IgA and atherosclerotic renovascular disease (ARVD)

From:
Marieta Theodorakopoulou, Greece
1st Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki

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Glomerulus lover – Representative image showing immunofluorescent staining for nephrin (green), FAK (red) and DAPI (blue) on a piece of human nephrectomy.

From:
Margaux Van Wynsberghe, France
IMRB Inserm U955, Hôpital Henri Mondor

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“Inception”- like, kidney-shaped nephron with a cellular crescent, from a patient with pauci-immune ANCA-associated renal vasculitis

From:
Panagiotis Pateinakis, Greece
Nephrology Department, “Papagergiou” General Hospital

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Kidney histological section in which a glomerulus forming the most iconic symbol of love; a big heart has been discovered in a hematoxylin-eosin slide (negative colors) after a hard day working on microscope

From:
Maria Lambropoulou, Greece
Pathologist & Professor of Histology-Embryology
Medical Department, Democritus University of Thrace, Alexandroupolis

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Kidney histological section in which the  “heart” represents collecting tubule (hematoxylin-eosin staining, 200×)

From:
Maria Lambropoulou, Greece
Pathologist & Professor of Histology-Embryology
Medical Department, Democritus University of Thrace, Alexandroupolis

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The Gift of Organ Donation

From:
Mayleen Laico, Philippines

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Transmission electron microscopy image of the murine renal filtration barrier. Random sections of the podocytes are sometimes reminiscent of prehistoric creatures.

From:
Oliver Kretz, Germany

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Adult human kidney organoids or tubuloids derived from CD24+ stem/progenitor cells. Red color in confocal image indicates E-cadherin (CDH1) staining, blue is DAPI.

From:
Yaoxian Xu and Rafael Kramann, Germany
Institute of Experimental Medicine and Systems Biology,  Medical Clinic 2, Faculty of Medicine, RWTH Aachen University.

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The Figure shows lenti-paired CRISPR-Cas9 gene editing for genetic disease ADPKD modeling in CD24+ derived adult human kidney tubuloids. Red color in Confocal image indicates CD24 staining, blue is DAPI, two cuts in DNA represent lenti-paired CRISPR-Cas9 gene editing in human PKD1 or PKD2 gene, white balloon-like structures represent ADPKD cysts.

From:
Yaoxian Xu and Rafael Kramann, Germany
Institute of Experimental Medicine and Systems Biology,  Medical Clinic 2, Faculty of Medicine, RWTH Aachen University.

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Organized Complexity shows the kidney’s complex function yet it is a very organized system

From:
Mayleen Laico, Philippines

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A nephrologist, immersed in passion, dances hand-in-hand with proximal tubule cells and podocytes. The dance unfolds on a green kidney, representing the earth, set against a blue cosmos background, symbolizing the nephrologist’s devotion to kidney research.

From:
Xinyu Dong, USA
Nephrology Department, Vanderbilt University Medical Center

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Drug delivery system targeting kidney

From:
Sara Gjeci, Meike N. Leiske, Adrian T. Press
University of Jena and Bayreuth, Germany

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Glomerulus Galaxy – Immunofluorescence images stained for C3 in a patient with lupus nephritis

From:
Marieta Theodorakopoulou, Greece
1st Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki,

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Immunofluorescence images of cultured urine stem cells (stained for CD133 (red) and CD24 (green), collected from healthy human urine.

From:
Chenyu Li, Germany

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Red blood cell cast indicating glomerulonephritis in a patient with AntiNeutrophil Cystoplasmic Antibody (ANCA) associated vasculitis

From:
Ralph Mohty, USA
MD MPH Stanford Nephrology

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Love hurts – Heart-shaped glomerulus in a nephritic kidney
Podoplanin – red; Alpha smooth muscle actin – yellow; DAPI – blue.

From:
Katharina Artinger, Austria

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Focal Segmental Glomerulosclerosis

From:
Anil Kumar Saxena, United Arab Emirates
Chair, Nephrology Division  Mediclinic Welcare Hospital Al Gahroud

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2,8-Dihydroxyadenine crystals in a rat kidney. PAS stain under polarized light.

From:
Barbara Mara Klinkhammer, Germany

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Drug delivery system targeting kidney

From:
Sara Gjeci, Meike N. Leiske, Adrian T. Press
University of Jena and Bayreuth, Germany

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Calcium oxalate monohydrate crystals in a patient with acute kidney injury, many of the dumbbell-shaped type seen under phase contrast and polarized light (Original magnification x400).

From:
Monarch Shah,
Fellow, University of Virginia, USA

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Calcium oxalate monohydrate crystals in a patient with acute kidney injury, many of the dumbbell-shaped type seen under phase contrast and polarized light (Original magnification x400).

From:
Monarch Shah,
Fellow, University of Virginia, USA

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Time projection showing filtration on the surface of a rat kidney acquired using intravital 2-photon microscopy.
A bolus of a small blue dextran appears first in the lumen of the Bowman’s space, proximal tubule lumen, then finally in the cortical collecting duct lumen.
Projection is 300 frames, close to 4 minutes.

From:
Ruben M Sandoval, USA
Indiana Center for Biological Microscopy

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A chronic kidney disease rat model showing the distribution of albumin (red) acquired in 3D using intravital 2-photon microscopy.
Fluorescent cast material (green) can be seen obstructing the lumen of a distal tubule.  The original image was processed to generate a tessellation with seamless borders and natural symmetry.

From:
Ruben M Sandoval, USA
Indiana Center for Biological Microscopy

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Electron microscopy confirmed the electron-dense crystalline structures within cytoplasm of proximal tubular epithelial cells

From:
Hélène Fank, Belgium
MD

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Immunohistochemistry for kappa light chains was strongly positive within these crystals (b, white arrow)

From:
Hélène Fank, Belgium
MD

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Light microscopy (Hematoxylin x400) showing intracellular crystalline inclusions within proximal tubular epithelial cells (a, black arrow)

From:
Hélène Fank, Belgium
MD

NDT Cover November 2023

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The Greening of Nephrology

From:
Mayleen Laico, Philippines

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Red blood cell cast – brightfield with Sternheimer – Malbin stain

From:
J. Romero Tafoya, México

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Bile cast and hyphae – brightfield with Sternheimer – Malbin stain

From:
J. Romero Tafoya, México

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Red blood cell cast- brightfield with Sternheimer- Malbin stain

From:
J. Romero Tafoya, México

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The Glomerulus ( Not Just Filters)

From:
Anil Saxena, United Arab Emirates
MD, FRCP, FASN Chair,
Nephrology Division Medical Director

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Kidney Transplant
Watercolour painting

From:
Reynaldo Noriega Flores, México

NDT Cover October 2023

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This image depicts a postnatal mouse kidney immunostained for the renal arterial tree with alpha-Smooth Muscle Actin (SMA, magenta) and glomeruli with podocin (Nphs2, cyan). Kidney was imaged with a LaVision Ultramicroscope II LightSheet using an Olympus MVPLAPO 2x/0.5 objective, a 2x Zoom, Sheet NA of 0.23, a Z step of 2.0µm and image pixel size of 1.54µm/pixel.

From:
Pierre-Emmanuel N’Guetta, USA

Lori O’Brien, USA
PhD, Assistant Professor

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Uric acid crystals, under partial polarization – original magnification x400 – from patient with marked volume depletion and AKI

From:
Jay R. Seltzer, USA
MD, Chief of Nephrology

NDT March cover 2024

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Renal tubular epithelial cell cast – brightfield with prolonged Sternheimer-Malbin staining – original magnification x1000 – from patient with bacterial endocarditis, acute kidney injury, and infection related glomerulonephritis

From:
Jay R. Seltzer, USA
MD, Chief of Nephrology

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Uric acid crystals in urine, under fully polarized light – original magnification x400 – from patient with marked volume depletion and AKI

From:
Jay R. Seltzer, USA
MD, Chief of Nephrology

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Red blood cell cast – brightfield with Sternheimer-Malbin stain – original magnification x1000 – from patient with hydralazine-induced vasculitis

From:
Jay R. Seltzer, USA
MD, Chief of Nephrology

NDT Cover July 2023

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This image demonstrates an abstract view of the transition between a proximal tubule and the thick descending limb of the loop of Henle

From:
Tiffany Caza, USA
MD/PhD, a nephropathologist at Arkana Laboratories

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B: Bright field, dark field and phase contrast image of cluster of calcium oxalate dihydrate crystals surrounding leukocytes

From:
Swetha Kanduri, USA
MD, Assistant Professor of Medicine

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Pen and ink sketch

From:
Maia Celeste Arbatin, Philippines
MD FPCP FPSN (#nephgirlsketches)

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Hydrangea Kidney

From:
Maia Celeste Arbatin, Philippines
MD FPCP FPSN (#nephgirlsketches)

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Kidney Trees

From:
Jeanine Verbeke, Belgium

NDT Cover August 2023

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Drawing for a family gift

From:
Dominique Couck, Belgium

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Eyelash sign in glomerular amyloidosis

From:
Boonyarit Cheunsuchon, Thailand
MD, Associate professor

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NDT history

From:
Sonja Djudjaj, Germany
PhD, Assistant Professor

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Water color kidney

From:
Sonja Djudjaj, Germany
PhD, Assistant Professor

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Giving hope

From:
Mayleen Laico, Philippines
MD

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Representative image obtained by STED super-resolution microscopy, showing strong positivity for IgA deposits  (orange) and a partial mild effacement of foot processes (stained with nephrin, cyan) in a biopsy of  IgA nephropathy patient. The biopsy specimen underwent optical tissue clearing before staining.

From:
Maria Lucia Angelotti, Italy
PhD

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Colorized transmission electron microscopy image of murine renal kidney cortex. Individual tubular segments are colored in green, blue and yellow, while a glomerular section is colored in red.

From:
Miriam Buhl, Germany
PhD

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Phase contrast image of cluster of calcium oxalate dihydrate crystals surrounding leukocytes

From:
Swetha Kanduri, USA
MD, Assistant Professor of Medicine

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Bright field image of cluster of calcium oxalate dihydrate crystals surrounding leukocytes

From:
Swetha Kanduri, USA
MD, Assistant Professor of Medicine

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Dark field image of cluster of calcium oxalate dihydrate crystals surrounding leukocytes

From:
Swetha Kanduri, USA
MD, Assistant Professor of Medicine

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Red blood cell cast – brightfield with Sternheimer-Malbin stain – original magnification x1000 – from patient with anti-glomerular basement membrane disease

From:
Jay R. Seltzer, USA
MD, Chief of Nephrology

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Secondary Toni-Debré-FANCONI syndrome – intracellular crystalline inclusions within proximal tubular epithelial cells

From:
Hélène Fank, Belgium
MD

Co-authors:
Antoine Bouquegneau, Christophe Bovy and Orphal Colleye

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Fibrinoid necrosis in a patient with ANCA-associated glomerulonephritis

From:
Boonyarit Cheunsuchon, Thailand
MD, Associate professor